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I'd be looking to upgrade Total Organ Failure by the start of month 10 or 11 depending on the plague. For me I did take some chances and went from Necrosis straight to Total Organ Failure or I even evolved Necrosis before all the islands were infected if I found it was getting too late. Once each country has a decent amount of infected it's time go for it with Total Organ Failure. If you're short on points I would go with Pulmonary Fibrosis and then Fever, leaving the other two. Fever, Diarrhoea, Pulmonary Oedema and Pulmonary Fibrosis are the four main symptoms of this category. Once you get that last one immediately evolve Necrosis and supplement that with mildly lethal symptom that also increase infectivity. Now you wait until every country is infected. This obviously then leads to Total Organ Failure. Coughing, Sneezing and Pneumonia - I would go for this grouping first because there would be a strong chance for Pulmonary Fibrosis or Immune Suppression to mutate first, thus saving some points. Get any first and second tier symptoms that didn’t mutate: Get any first tier transmissions that didn’t mutate (Air 1, Insect 1, Blood 1, Rodent 1) Get Drug Resistance 1, Genetic Hardening 1, Cold 1 and 2 Start in India (the seaport is important)
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Rash, Sweating and Skin Lesions - these work well because they're highly infectious for a cheap price and it leads to Necrosis which is just wonderful for fast killing and re-infection of survivors with corpses Note that if you manage to do this in less than 450 days you should get the 3 biohazards.ĪTP Boost, Base Oxidisation, Teracyte, Extremophile, Patho-Stasis So let's look at the 7 similar plagues first which are Bacteria, Virus, Fungus, Parasite, Prion, Nano-Virus and Bio-Weapon.